Repbase Reports

2007, Volume 7, Issue 4
April 30, 2007
Copyright © 2001-2016 - Genetic Information Research Institute
ISSN# 1534-830X
Page 146

IS4EU-2_DR

A family of autonomous IS4EU transposons - a consensus.

Submitted:
29-Apr-2007
Accepted:
30-Apr-2007
Key Words:
IS4EU; DNA transposon; Interspersed Repeat; IS4EU-2_DR
Source:
Danio rerio
Organism:
Danio rerio
Taxonomy:
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Danio
[1] Authors:
Kapitonov,V.V. and Jurka,J.
Title:
IS4EU, a novel superfamily of eukaryotic DNA transposons.
Journal:
Repbase Reports 7(4), 146-146 (2007)
Abstract:
DNA transposons from the IS4EU superfamily are characterized by the TA target site duplications. These transposons are wide spread in metazoans, including fish, frogs, lancelet, sea urchins, sea squirts, insects and cnidarians. Autonomous IS4EU transposons encode two proteins: the IS4EU-TR transposase, which is similar to the IS4-like bacterial transposases, and the ISEU-EX DNA exonuclease. Based on the conservation of both proteins in highly divergent transposons, is is clear that they are necessary for transpositions. IS4EU-2_DR is a consensus sequence of a young family of autonomous IS4EU transposons that were active in the zebrafish genome in a last few million years. The IS4EU-2_DR transposon is characterized by 13-bp terminal inverted repeats, TA target site duplications, and it encodes two proteins: (i) the 475-aa transposase, IS4EU-1_DR1p, composed of the THAP DNA-binding domain and catalytic "DDE" domain, which is conserved in all IS4EU transposases, and (ii) the 515-aa IS4EU-1_DR2p exonuclease. Questions and comments send to Vladimir Kapitonov.
Derived:
[1] (Consensus)
Download Sequence - Format:
IG, EMBL, FASTA
References:

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