;ID HELITRON1 DNA ; ATH ; 15809 BP ;XX ;DE HELITRON1 is a DNA transposon, a consensus sequence. ;XX ;AC . ;XX ;DT 31-MAY-2000 (Rel. 5.8, Created) ;DT 24-MAY-2001 (Rel. 6.2, Last updated, Version 2) ;XX ;KW DNA transposon; helicase; replication protein A; HELITRON class; ;KW ATREP; HELITRON1. ;XX ;OS consensus ;XX ;OC Arabidopsis thaliana ;OC Eukaryota; Plantae; Embryobionta; Magnoliophyta; Magnoliopsida; ;OC Dilleniidae; Capparales; Brassicaceae. ;XX ;RN [1] (bases 1 to 15810) ;RA Kapitonov,V.V. and Jurka,J. ;RL Direct submission (May, 2000) ;XX ;RN [2] (bases 1 to 15809) ;RA Kapitonov,V.V. and Jurka,J. ;RL Update (May, 2001) ;XX ;RN [3] ;RA Kapitonov,V.V. and Jurka,J. ;RT Rolling-circle transposons in eukaryotes. ;RL Proc Natl Acad Sci USA 98(15), 8714-8719 (2001) ;XX ;CC HELITRON1 is a DNA transposon. ;CC It encodes a DNA helicase-like 1697-aa protein, ATHEL2p. ;CC HELITRON1 encodes also proteins ATRPA1H1p and ATRPA1H3p ;CC similar to the replication protein A. ;CC There are several copies of HELITRON1 in the ;CC genome; they are ~98% identical to the consensus sequence. ;CC Approximately 2% of the A. thaliana genome belongs to molecular ;CC fossils of non-autonomous elements transposed recently (<10 Myrs) ;CC by autonomous HELITRON1-like elements. ATREP1-ATREP12 are families ;CC of non-autonomous elements transposed by HELITRON1-like DNA ;CC transposons. All these elements share the same 5'-TC and ;CC CTAG-3' termini, the AT target site, and they do not generate ;CC duplications of the target sites upon insertion into the genome. ;CC ;CC ATRPA1H1p: ;CC MAATFAYLKDVRPYKNAWRVQVKILHSWKQYTSNTRETIELVISDEYGKKMHATVKKELV ;CC SKFVHKLIVGEWVFIEIFGLTYASGQFRPTNHLYKMAFQVRTEVMGCASVSDSNFLTLAP ;CC FSKIQSGELNPHMLVDAIGQIITVGELEELEANNKPTTKIDFEIRDQMDERMQVTLWGTY ;CC AQQVYRACQESEGKNVIFLIRFAKIKSYKGIFSFFVPIPFLSILHDLWSLKCYETAGVKS ;CC LSNSFDASQVHVNPDFPEAHHFSQTLPNDGAICVFRARVPRFEMVAVKRIDYSEYTRNTI ;CC EDLLSSTEVGKVRVLCTIYAIDTDWAWYYISCKTCNKKVNHIHAGVNGVNNKGKKPRFWC ;CC DTCKSVVTNVVSRYMIYAKVMDSTGEAKLLLFDSICSEIIGESATSVLNGSVDEIEDPED ;CC LPDSVKNLIGKTFLFLVWVEKDNISDGKEIYKVSKVLLKDGLLEEQLLEDSAEHVNPASI ;CC VSGDQVLLMLENGNGSPDSTTPSSKRVYARETSGSEGSSSSKKVCVVPLDLEKSLSENAE ;CC HGVALNPQVADSKEVTVPTEVKTSKVPVETENDQALVPATVVVKQEVKKEMARNMATNWV ;CC ICVKVLCIWDHPPNVNGDVTTMILVDAKHHRIVATIPRLNLREKFRRVLQEGFWFNISQF ;CC RVIPSTHRVETWDTVVFRMSELVKSDFTDYLFPNELEDSATDNVVDVTDAIGVVASVSSI ;CC KRFPYVCNKGETDYEARYVSFELMDNWEQKLKCVAVGSCCEEFVTKWSRRITRPTYNYEP ;CC VVCVVRFWRIASIDGENVLTSEFGCSRLHIDPSFPYFDLASYLRSFKDADDQEVTMEPVT ;CC EA ;CC ;CC ATHEL1p: ;CC MSCRRVAAAAPGDVTTTAISDDPIHPFIVIGRAIHLPPFNFIRLATLLNLIRLATHLARC ;CC LRTILRSLYHKVTMLVCSFERSGLTSIGRKNLHQPKTASTIPFSDLTKPNLQASPQNLDA ;CC SMTPATAYTVNTGQELSNPYSCISNQTQTPVMSTEYSHIRNLQAEFEKASTSATNPRAEA ;CC TINSDTSSDDENMANMMFDGAVYESDTDVDQNYSLSSTDDESADTTTIQTESESMANVST ;CC HEVEDIVSQLSENDIELDTFSSQMDIFMIPTESTQTANVPESAPKKRGRPRLAVTKQMRM ;CC KQIRQQNKPGYLDHGDPTFKCKYCGAMMWYDERIRKKETNKESGFTLCCGEGSVKLPFLK ;CC ESPDLLKNLLSGNHPLSKHYRDNARTFNMVFAVTSLGGKVDKSMPKGRGPAMFRLQGGNY ;CC HLIGSLKPTPGDYAKYSQLYIVDTENEVENRAIVIGKGKNAKPASGKPNLDKNLIEVIIK ;CC MLNRCNPYVRRFRTARERIQTNDEEPFHMRIIADRQGVEGRTYSMPTTSEVAALIPGDFR ;CC HGMPDRDIVIGKKSNGHLKRINQIHISYLALQYPLIFCYGEDGFRPGIEKCSKSKSKKKN ;CC KKCISMRQWFAFRIQEREVECQTLLRSKRLFQQCLCDAYTTIESNRLNYIKFNQSKLRCE ;CC NYTSVKEAAAAGATTMEEEGNQLLIPASFTGGPRYMVQSYYDAMAICKHYGFPDLFITFT ;CC CNPKWPEITRYCDKRGLNPEDRPNIIARIFKIKLDSLMNDLTVKKMLGKTVASMYTVEFQ ;CC KRGLPHAHILLFMHAKSKLPTADDIDKLISAEIPDKEKEPDLYEVIKNSMIHGPCGSANV ;CC NSPCMVDGECSKLYPKKHQDITKIGSDGYPIYRRRKTDDYVEKGGIKCDNRYVVPYNKKL ;CC SLRYNAHINVEWCNQNGSIKYLFKYINKGPDKVVFIVEPTQQTTAGDSETPQQEQGSAEK ;CC KKNEIKDWFDCRYVSASEAVWRIFKYPIQHISTPVQKLSFHVEGKQPAYFDPKSNIEDVL ;CC ERVANADSQFMAWLTLNRRNAVGKNGKRARECLYAEIPAYFTWDGENKSFKKRTRGFSIG ;CC RIHYVSRKMEDEYFLRVLLNIVRGPTSYAEIKTYDGVVYKTFKEACFARGILDDDQVFID ;CC GLVEANLTLTETEIKNYTLQEIEKIMLSNGATLEDIDEFPKPTRDGIDNSNRLIVEELRY ;CC NRESNLKEKHEEWKQMLTPEQRGVYNEITEAVFNNLGGVFFVYGFGGTGKTFIWKTLSAA ;CC IRCRDQIVLNVASSGIASLLLEGGRTAHSRFGIPLNPDEFSVCKIKPKSDLANLVKEASL ;CC VIWDEAPMMSRFCFEALDKSFSDIIKNTDNKVFGGKVVVFGGDFRQVLPVINGAGRAEIV ;CC MSSLNASYLWDHCKVLKLTKNMRLLANNLSETEAKEIQEFSDWLLAVGDGRINEPNDGVA ;CC IIDIPEDLLITNADKPIESITNEIYGDPKILHEITDPKFFQGRAILAPKNEDVNTINEYL ;CC LEQLHAEERIYLSADSIDPTDSDSLNNPVITPDFLNSIKLPGLPNHSLRLKVGAPVMLLR ;CC NLDPKGGLCNGTRLQITQLCTQIVEAKVITGDRIGHIVLIPTVNLTPTDTKLPFKMRRRQ ;CC FPLSVAFAMTINKSQGQSLEHVGLYLPKPVFSHGQLYVALSRVTSKKGLKILILDKDGKL ;CC QKQTTNVVFKEVFQNID ;CC ;CC ATRPA1H2p: ;CC MAERNYIPDLNLHRNNHIIYVKILSMWDLQSMIKPTPSTMILCDVKGNKIDARIPWGEYM ;CC SNFKTSLFEGKWYYLQHFRLKRSTTIPKYTDFHYEIEFMWHTKMWAVSDRAEQSSLKFIH ;CC ADEVNGESEDHVVDVIGVITTVSTVSSFPYCCPEGETDYDARYVIFTIRDNHERIITCVA ;CC RGSACESFLSKVYRLIGSKTYNYEPITTVLRFFRTSMFKGSKALISEYGCSRVFIEEEFP ;CC DFDVSSEPVGNVEGRIEYVAKD ;CC ;CC There are several other families of HELITRON1-like transposons ;CC in the A.thaliana genome that are only 60-70% identical to the ;CC HELITRON1 consensus sequence. ;XX ;DR [2] (Consensus) ;XX ;SQ Sequence 15809 BP; 5053 A; 2664 C; 2818 G; 5272 T; 2 other; HELITRON1 tctacatatacatttttggggacgatttgtgtcgaaaaatcctttttcaatttcgatattgtatgtttag tccctacaaaatcaatcagacaagatattttctttaggacaataaccaaatttttgctcaactattcacg tattgcactaattacttgcctaaacatataaattgttaagtactaccctcataaattgcacacattaatc ccttgaaactctactaattcaatattacacgaaataatatttcctaaaaatccgaacaaccaaataacta accatatctttacttacttcattccaaaatctcgaaatatttactacactcttaccaaatattcatattt cgatatcacatttctataagttaaacgattattaatcatgcattaattccataaaccttaaaggaaccct caatatatcatataatcttacatatggtatagtcaatatatttttacacattctaaaaatcatcatcaat tcgaaattccaatatatcacctcgaaaattaaatttcgccaactataatattatccaaattgttatggat tattgccttccaaaaattttatccgatcgaatcatctattctctccactcctcattcatagcaattctgt ttcctgatttacatatatcaccttaactacaaaatcttttaacattcgcttgccagtcaagacataatct aaatcacgcaatattccatcttctaaaccatccaaatcattctgttttgaatgtacaagcgtaaaaataa gggcaaatgcatctaccatatctcgacagtttgattcagaatcaaatcaaaatctaaatacggcatttcg attattattttgcacttatgatactcaagcatattcctattctaaaccattcagaatcattctgtttcta aagaatttacgctctaaatctttgcaaataaatgtttaaagattcactcggctactataaatacgcttct catatcattccatttcatcatcactcacaccgcaaacgagagatcaaagcaattatacattttgagaaat ggctgctacattcgcataccttaaagacgtgaggccttacaaaaacgcatggagagtccaggtcaagatt cttcactcttggaagcagtacacaagcaacacccgtgaaaccattgagttggtcatctctgatgaatatg taagaattactgttatctatgcaaaatttacgtttacatatacacaagtgctaatatagatttctgttgt ctttgtcataaggggaaaaaaatgcatgctaccgtgaagaaggagttggtttctaagtttgttcacaagc ttattgttggcgaatgggtcttcattgagatttttggtcttacctatgcgtctggccagtttcgcccaac caaccatctatacaagatggcgttccaggttagaactgaagtcatgggttgtgcttctgtctctgactcc aacttcttgactttggcgccattttcaaaaatccagagtggtgagcttaaccctcacatgttggttggtg agttttctgattctatattatatttttgctttattccattcacttgctatcattagattatgaacacagt catgtttcactgcagatgctattggccaaatcattactgttggtgagttggaggaactcgaggctaacaa taagcctacaacaaagattgactttgagatcagagatcaaatgtaatgtctatatcttattagtttattg cgatcttatttgtttattgcttatcaaagaaagtgtttgtttcgattcatttgttctcatagggatgaga gaatgcaagttactttgtggggaacatacgctcagcaggtttacagagcatgtcaggaatctgagggaaa gaatgtgatttttctcattcgttttgccaaaattaagagttacaagggtatattcagtttctttgtacct attccttttctttccatactgcatgatctatggtcacttaaatgttatgagactgcaggtgtgaagagtt tatccaactcatttgatgcatcgcaagtacatgtcaatccggacttccctgaagctcaccatttcagtca aacgtaaatgcatctactctcaacacaatctacttttagttgacttctttatgtgctattgatcatcttt ttatccaaatgcagacttccaaatgatggtgctatttgtgtgttccgtgcaagagtcccacgttttgaga tggttgcagttaaaaggattgactacagtgagtacacaaggaataccattgaagatctgcttagctcgac tgaggttatattcagctaacttatctcaaagtttagaaatctaactatcatcagtatctaatgtgttctg atattttatataggttggtaaagtcagagttttgtgcacaatctatgcaattgatacggattgggcttgg tattacatcagctgcaagacatgtaataagaaagtgaatcatattcatgctggtgttaatggagtaaaca acaagggtaagaagcctagattctggtgtgatacatgcaagtctgttgtaaccaatgtggtctctaggta aatacatttctttgaagattatatttacatagcatactactttgaaatattttattggaactgtgtgtat agtttggaaattaagttcgtaaaattttattatatgcaaggtacatgatctatgcaaaggttatggatag cactggtgaagccaaattgcttctgtttgattcaatttgctctgagatcattggcgagtctgcaacctct gttcttaatggatctgttgatgaggtgtgtttcttaaagttgtcccgtgtctactttatgtatactgaca tataaatatatagagaactcaaatagctatttacactcttccagattgaggatccagaagatcttcctga ttctgtaaagaatctgattggtaagacatttctgtttctggtgtgggttgagaaagacaacatctcggat ggaaaagaaatctataaggtttcaaaggtgcttctgaaggatggactactagaggaacaattactagagg attctgctgaacatgtgaaccctgcatccattgtgtctggtgatcaggtatttcacacaacatttcaagt tacattcttcattacaatcataaagttcataagagttttggcaatttctaactctatatattgcaggttc tacttatgctggagaatggtaatggatcgccagactctacgactccatcttcaaagcgtgtttacgctag agaaacgagtggctctgaaggttcttcaagttcaaagaaggtgtgtgttgtaccattagacttggaaaag tctttatctgagaatgctgaacatggagttgccttgaatccgcaggtggctgattcaaaagaagttactg ttccaactgaagtcaaaacatcaaaggttcctgttgaaacagagaatgaccaagcacttgtcccagctac tgtcgtggtgaaacaagaagtcaagaaagagatggctaggaacatggctactgtaagggtcaaagtggag aagaacaagtgatctacttatctatttcttttaataagtgatgcttcttgaactgtgtttggtcactgaa gctatgttttgaattttttttttttttttattggattatgttcgtgtttttgttttcgaagttattggat ttcatgttttggattatgtttcatctttaattttggagttaatcttaaaattattttattaagcttatat gttcgatcattactaattttgtagccatctatatgaaaacatgcaatctcagttataatgttacagttag agggtccaaagaaacttaccatttcatgttgtatatatgtattcgactggcttcagacttttaatgaatg actttagtgtatacctgtatcaataagttaaagtttcattaacaatttgctattccaatcttttagatat aatatagatttcatactatattataaaatgaaactatacaaaagatcaaatcaatattatgtcaatatta tgtcaatcttttgacaatcttacatatagattcactatgattaacatctataactgtctagatattagga aattgtcttattcgtaatcattatacatctatgtctacgatatcttattagattttctcgatatgtcata ttgacgtcatcatcgagaacccgcggaacgattcgtattttcttattttaaaaaacatctgccattcatt gtatcttttcaacttatatatatattgagtaactgttccttttcgatctcaaccctaaaagataaagcat aaacattaaatccaaagagagacatccgtggcttatattcacaaactcgaagatttgaacttgatgaaca atcagaattgggttatatgcgtgaaagttctctgtatttgggatcatcctccaaacgtgaacggtgatgt tacaaccatgattttggttgatgcaaaggttagtctttcaaattcatctgctcttttagatcgttttttt ttgtggcttggtctattgcatgtcatcaaaatatcttgcgggttctacttagtctttttattttgtcaac ttaacagcatcacagaatcgttgcaaccatacctagattgaatttgagggaaaaattcaggcgagttctc caggagggtttctggtttaacatctctcagtttcgtgtgattccctctacacacagagtagaaacgtatg tgttgaaccgtctccatatcatgttcagatgggatactgtagtgttcagaatgtcagagttagtgaaatc tgatttcacagactatcttttccccaatgaacttgaggactctgctacagacaatgttgttgatgttact ggtatgtttataacgatcctaattctttagatcatttcatgagtttatatttgagtactctgctgcagac aataactagcttttgattttttgttttcatagatgctattggtgtggttgcaagcgtttcttctatcaag aggtttccttatgtctgcaataagggtgagaccgactatgaggccagatatgtttctttcgagcttatgg ataattggtaagtttataagttatagatttaggattagttgatctagcttgcagactttacatttagatt attgcgtgtgattatttaccacagtctaccaatggtacagggaacaaaaactcaagtgtgttgctgttgg ttcatgctgtgaagagtttgttaccaagtggtctaggcgtatcactagaccaacatacaactatgaacca gttgtatgtgttgtgcgcttctggagaattgcttcaattgatggttagtattctaaatctgctagataat tgtattgagttgtgtcccatgaaacctgtgtttacatttaaattatgttctgttttgacaaatgaaacct gtgttttttctgtgtgtaaggtgaaaacgttttaacgagtgagtttggatgttcccgtctacatatagac ccaagcttcccttactttgatcttgcaagttatctgtaagtctagcaattggttttaaatttctgtagtt tacaattaagaacagttacttagttttataatctattgtctctgtaccaggcggagtttcaaagatgctg atgatcaagaagtgacaatggaaccagttactgaagcttgaagctatttgggtcggtttgttcggttttg ggagaaattcggttttaattttttttaccgaatagacccaaattaaaattcggttcgggtcggttcggaa gtcggttcattcgggtcggttctagaaattgtgttccgaacttaaaaccaaacaaaaatttattcggttt ctacggtttttaattcggtttagatatttaaaaaaaaaattacactaccaaaaatcctaatccaaacaaa ttacccactacaaattaataaaaagcccaaaatacaattcaaaaaagcccaaaacaaaaactaatagccc aaccctagaaaatattagggttttgaccaaaagatatgagctgccgaagggttgcggctgcggctccagg tgacgtaacgacgacggccatctctgatgatcctattcatcctttcatcgtcattggccgtgctattcat cttcctcctttcaacttcattcgccttgctactcttttaaacctcattcgccttgctactcatcttgctc gttgccttcgtacaattcttcgttctttatatcacaaagtaacaatgcttgtatgtaaggatgacgagag cctatgatgttttggatccaatttataaatcaaaagaagaagcaacgaagaaagaagagcgtacggagat gaagtgataaagtagaatagaagagatgagatatttgtttagatgtgagaagcaagatgagctttctcga gaataagaggcggagccgaagcgaagaagataaacaaattagggtaacttagttaggtttacacttatat atggctcctattaatggacttaggtttagagtaataaaccgatcggtccgattaccgaaccgacccgaac cgagtaccgttgcaacaaattaattcaaccgatcagtttagacttctctcttcggtttacgccgaaaccc gaaattttcgggttaatcagttcggtttcttcggtttactccgaactagttgttatgtttttagtacttt ttaacattatgttatgtttttggattgaaacatatctattcctatcttataacttttatgatattgtgtt ctttaaagtattcaattcttaaattttaatttcgttttaacatatatgatattgtcactaatttacaaaa ataattatacctgtaacagattcagaacattagcagaatattggttcttggagaatcattaaatccaaaa tatatgacagttgagaaaggaaaaaatatattaccaacttcgatttggtactccaaattggttacataat ttgtaatcgtctggtatattgtgtagcaaagtaaatatactttatgtagaaaatgcgagaacagagcaag ttgatatatttactcacctaccaaatatttccttaactaacaaacagatcctctctaatcaagtatggac tctattacatttactttcaacaattctataaaatcttataccagttatcttaaatcactcaatactcatg acagtctagagtattgaaatgggaaaaaaaaacagccatgctctgtttgatctaatttcacctccaccct cagagaagagaccacgtataggtcaaataacagcttcacaaagccaacttactcagcgtaatggatctaa ttctaatggttatgtgtctattagatcagttttcaatacagttttcagagatatcactaatttgattcag caacttctatacagtattcacatggtactgtcattactatacaatatccaactttcagattctatctgct ttacaagatttgcaaatggttgtcacagttacttagaatgtgtttgaactactcgcaggttcatttgaaa gatcaggacttacctcgattggcagaaaaaatttgcatcagcctaagacagcttctactattccatttag tgatctcaccaaaccaaatcttcaggcatcacctcaaaatttagatgcatcgatgacaccagctactgca tatacagtgaacacaggttagttattctatatatatcttttagttctccaaactactctgtctattatgt aatttttatcttttaaatatccgaatcattaatctaaatcttattttatgtattacaaggacaagaactg agtaatccatattcatgtataagcaaccaaacacagacaccagtgatgtcaacagagtattctcatatac gaaatttacaagcagaatttgagaaagcatcaacatctgctaccaatccgagtaagaatatataggttta caaacatttctcttaaagtatcattttatataagttgtgttaatttataaattttcgatgtgatcatagg agcagaagctacaatcaattcagatactagcagtgatgatgaaaacatggccaatatgatgtttgatggt gcagtatatgaaagtgatactgatgtggatcaaaattactctcttagtagcactgacgatgaaagtgcag acacaaccacaatccaaacagaatctgaatcaatggctaatgtatctactcatgaagtagaagacattgt gtcacagttaagtgaaaatgacatagaacttgatacattcagctcacagatggatatatttatgattcca acagaatctactcaaacagcaaatgtcccagaatctgctcctaaaaaaagaggtcgtccaagattggctg taaccaaacaaatgagaatgaaacaaattagacaacagaataagccaggtattgtttgttatctaaattc ttcattgtcatacatttatctcagatattgtaatgcaaacccaaattatagttgtttcaggttatcttga tcacggtgatcctacattcaagtgtaagtattgtggtgctatgatgtggtatgatgagcggattagaaaa aaggagacaaacaaagaatctggtttcactctttgttgtggagaaggaagtgtcaaacttccatttctga aggagtccccagatcttctcaagaacctcctctcaggaaaccatccactctctaaacattacagagacaa tgctagaacttttaatatggttttcgcagtgacctctcttggtggtaaagtagataaatctatgcctaaa ggtagagggccagccatgtttagattgcaaggtggaaattaccatttgattggtagtttaaaacctactc ctggagattacgctaagtattcccaactatacattgttgatactgagaacgaagttgaaaacagagctat tgtcatcgggtaacatagctcatatcttacatgctttacatgtctgtttaggttatgcactgatatggat ttaaaaatagtttactgttgtttttcatctaatgtagcaagggaaaaaatgctaagccggcatcaggaaa accaaatttggataagaatcttattgaagtcattataaagatgcttaaccgttgcaacccttacgttaga agatttaggacagccagagagaggattcaaacaaatgatgaagagccatttcacatgcgtattatcgcag atcgtcaaggtgttgagggcaggacatatagtatgcctaccacatcagaggttgcagccttgatccctgg agattttcgacatggcatgcctgatagggacattgttataggaaaaaaatcaaatggtcacctaaagagg attaaccagattcacatttcctatttggctctgcaatatccactaatattttgttatggcgaagatggct tcagacctggaattgagaagtgttctaaatcaaaaagtaagaagaagaataagaagtgtatcagcatgag acaatggtttgcattccgtattcaagagagggaagttgagtgccaaactctattacgttcaaagaggttg ttccagcagtgtctctgtgatgcttataccactattgaatctaacagattaaactatatcaagtttaatc agtcgaaacttcgatgtgaaaactacacatctgtaaaagaagcagctgcagctggagcaaccactatgga agaagaaggtaaccaactactgattccagcttcattcactggtggtcctagatatatggttcaaagctac tatgatgcaatggctatctgtaaacattatggttttccagatcttttcatcacttttacctgtaacccaa agtggccagagataacaagatactgcgataaaagaggtttaaatcctgaagacagacctaacattatagc ccgtatttttaaaatcaaactggattctctaatgaatgatttaactgtgaaaaagatgcttgggaagact gttgcatgtaagtatggtttagtatactacattactatttatcaaaatcatctaattcgaaagtactcat tctgttttgtttgtgcttgcagcgatgtatactgttgagtttcagaaaagaggcttgcctcatgcacaca ttctcttattcatgcatgctaagagcaaattaccaacagcagacgacattgataaacttatttctgctga gattcctgacaaagaaaaagaaccagatctatacgaagttatcaaaaactccatgattcacggtccatgt ggttcagcaaatgtcaattctccatgtatggttgatggagaatgttctaaactttatcccaaaaaacatc aagatataaccaagattggtagtgatggttatcctatttatagaagaagaaaaactgatgactatgttga gaagggtggtattaaatgtgacaataggtatgttgtgccttataacaagaagctttctcttcgttataat gctcatatcaatgtcgaatggtgtaaccagaatggctccattaaatacttattcaagtatatcaacaaag gaccagacaaagttgtcttcatagttgagccaactcagcagactacagctggtgactctgaaacgccaca gcaagaacaaggttcagctgagaagaagaagaacgagatcaaagattggttcgattgcaggttagtctat ttctttgttatttcttaattatttggtttggtttcatattgaataaaaaaatcattctaatacataatga attgtttgcagatatgtttccgcatctgaagctgtttggagaatttttaaatatccaattcaacatatat caacgcccgtccagaaattatcttttcatgtagaaggaaaacaaccagcttattttgatccaaagtcaaa cattgaagacgttctagaacgagtagcaaatgcagactctcagtttatggcctggctcactttgaataga agaaatgctgttggaaaaaatggtaagcgagctagagagtgtttgtatgctgaaattcctgcatatttca catgggatggagaaaacaagtcgtttaaaaagagaactaggggtttttcaataggtcgcattcactatgt ttcaaggaaaatggaagatgagtattttctcagagtactcttaaacattgtgagaggtccaacgagttat gctgaaatcaaaacctatgacggtgttgtatacaagactttcaaagaagcatgttttgcacgtggtattc ttgacgatgatcaggtttttattgatggcctggtggaagcaagtcagtgttgttttggagattatctcag gaattttttttgcaatgcttcttctctcggattctttgtctagaccagcacacgtcaggtcacaaacgtg gcatcttttagcagaggatattttgaaaacaaaaagagatgagttcaaaaatccaggtttttatattttt taccttccatgtttccttacttatagagttttaatgttttcacgttatttgttttaatgttttcatctaa aattttgcagacctaacactcactgaaactgaaattaagaattacacactacaggaaatcgagaaaatta tgctgtcaaatggagcaaccttagaagatattgatgagtttcctaagcctactagagatggtattgataa ttcaaatagactcattgttgaggagttaagatataaccgtgaatccaacctaaaagagaagcatgaagaa tggaaacagatgctaactcctgagcagagaggcgtatacaatgagattacagaggcagtttttaataatt taggtggagtcttttttgtgtacggttttggaggtacagggaagacttttatttggaaaactctgtctgc tgctattagatgtagagatcagattgttcttaacgtcgcctccagtggcattgcctctttgttgttagaa ggtggtcggactgcacattcaaggtttggtattccattgaatcctgatgagttctctgtatgtaagataa aaccaaagtctgatttggcaaatttggttaaagaagcgtctttagttatatgggatgaagcaccaatgat gagcaggttttgttttgaagctttagataaatctttctccgacattataaaaaacacagacaacaaggtt tttggtggaaaggttgttgtttttggtggtgatttcagacaggtgcttccagtaattaatggtgcaggga gagcagaaatagtaatgtcatcgcttaatgcttcgtatctttgggatcactgcaaggtgttaaagttgac taagaacatgagactactagcaaacaatttgagtgaaactgaagctaaagaaattcaagagttttctgat tggttattggctgttggtgatggtaggataaatgagcctaacgacggtgtggctataatagatattccag aagatttgttgattaccaacgcagacaagccaatagaatcgatcaccaatgaaatttatggagatcctaa aatcctacacgaaatcactgatcccaaattctttcaaggcagagctatattagcaccaaagaatgaggac gtaaacacaatcaatgagtatttgctagagcagttgcatggtcagtgcacttttactcttcagtttaaag tttataatctttatatgcaatctattttttattgaatatacaactgacatacattcaatttgttttttgt ttcagctgaggaaagaatttatctatctgctgattccatagatcctacagattctgattcacttaacaat cctgttatcactccagattttttaaacagtatcaagttaccaggtttgcctaaccattctttgcgtttaa aggtcggtgctcctgttatgttactacgaaatttggatcctaaaggtggtctatgcaatggcactaggct tcagattacgcagctatgtactcagattgttgaagctaaagttattacaggagacagaattggtcacata gttttgattcctacagtgaatcttacacctacagacactaaacttccattcaagatgcgtagaagacagt ttccactctctgttgcattcgctatgactataaataagagtcaaggtcaatctctagaacatgtaggact ttacttgcccaaaccagtgttctcccatggtcagctttatgttgctttgtctagggttacctctaaaaag ggtttgaaaatcctaatactagacaaagatggtaaacttcagaagcaaacaaccaacgttgttttcaagg aagttttccaaaacatagactgattacattgctgccagtctatgttccaagcatttgagaaaggtattct tcatcaacctttattcactttatatactttcatttatggctgttaaacccccacacagtaactaacaagt agtatttgatctataatgtcacaggattatttacattattctgctgaagaggattaactagattcgcatt actaaagtagtcatagagaaggattatgacatcttctccgacttcaagttcctcatattttaataaggca actatgttagtatgtcttaactaaattggtttgattgaatatttaaaattagttttggaatttaaacata atcaaccattatttatattcttgttgcatccaaatactttattggaattatctactaacatatatgcaat cattagcaacaaagactttactatattgtgattggctacagaatcggttagcacataattagagattgat taaatgatttaaacggatatatagcaagaaacctttcgtatatattcactgaatctatattcatctttca tcgtgcttcttcaatatatatataagaccaatatttggttaacttccctcaatctatcttttctaaaaat ctgaacaatcaccatccaaacttccaatggccgagagaaattatatcccagatctaaatttacacaggaa caatcatattatatacgtaaaaatattaagcatgtgggatttgcagtctatgatcaaaccaactccgtct accatgatcctatgtgatgtgaaggtgagtatctatgatgtatatttgaattgttattctggtttttgct ttctattattttccaacaaattttatatggttctctttttattcagggaaacaaaatcgatgctagaata ccttggggcgagtatatgtccaattttaagactagcctatttgaaggaaagtggtattaccttcaacact ttcgattgaagagatcaacaacaataccaaagtacacagattttcactatgaaatcgagtttatgtggca cactaaaatgtgggctgtaagtgatagagcagaacaaagttctctcaaattcatccatgctgatgaagtc aatggagaatctgaggatcatgtagtcggtaatataagtcttaattttatagtatatcatttcttgcaat tgttattccttagtactaatattttgattaatactgacttattgttctgttattgttagatgttattgga gttataacaactgtctcaactgtgtcgagttttccatattgttgtcctgaaggggaaacagactatgatg ccagatatgtgatatttaccatccgagataatcagtaagttaacaatcatggacttatattggtatagaa attcgttaggaacagacatatatgtgtagtatgataaatttgtattctctttggttgtagtgagaggatc ataacttgtgttgctagagggagtgcgtgtgagtcttttctatcaaaggtttatcgacttattggttcga aaacttacaactacgagccaatcactacagtgctccggttctttagaacttctatgtttaaaggttagtt tatatacgttaatatgttatactcttaccttagaatgttaaatcatgtgatatataactaatcaacagaa tgataacaaatattataggatctaaggccttaatcagcgagtatgggtgttcaagggtcttcattgagga agagtttccagactttgatgtatcatgttacatgtatgtgaaagacattagatactggtgatagtttgtt tattagatactaagttattcaagaagtttgacatctttttatgtttttgttacaacaatttttttgcagc tgaaccagttggaaatgttgaagggaggattgagtatgttgctaaggactaatcctagagtcagattcgt cggaagaaggatttgtttaatctatttaccttgctttcaaaaatcaaattattcattcttaagttgattt tgtttttgtcttttgaactattgtttgtaagaatgatcataaattgtgttcattttgggagagattgttt cagtttaaaaacaatctaagtattatataataaatatttagtatadaaattaaattattgtagaaattta aatacatcatatacttcatataacaatagagcasccatgtaattttaatgataattacagttacaatcca aaaattaaatttcaaaccaattgaatcatatgaatttacatgtaataaaatacgatgtatataaatagaa tattatacatgtttgcggaactttacaaaaccagaccgaaacatacaaatataatcacccatgtcaataa atataaatatatagtaaaaaatacaaattaactataatgatttaactgtcaattatattataatgaaacc atcatattacgatcaaacgcaaatactcaacctgcggtgtaccgcaggtccgtatctag1