Repbase Reports |
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| 2007, Volume 7, Issue 4 |
| April 30, 2007 |
| Copyright © 2001-2016 - Genetic Information Research Institute |
| ISSN# 1534-830X |
| Page 143 |
IS4EU-1_AA |
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A family of autonomous IS4EU transposons - a consensus. |
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Submitted: 29-Apr-2007 |
Accepted: 30-Apr-2007 |
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Key Words: IS4EU; DNA transposon; Interspersed Repeat; IS4EU-1_AA |
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Source: Aedes aegypti |
Organism: Aedes aegypti |
Taxonomy: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae; Culicinae; Culicini; Aedes; Stegomyia |
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Authors: Kapitonov,V.V. and Jurka,J. |
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Title: IS4EU, a novel superfamily of eukaryotic DNA transposons. |
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Journal: Repbase Reports 7(4), 143-143 (2007) |
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Abstract: DNA transposons from the IS4EU superfamily are characterized by the TA target site duplications. These transposons are wide spread in metazoans, including fish, frogs, lancelet, sea urchins, sea squirts, insects and cnidarians. Autonomous IS4EU transposons encode two proteins: the IS4EU-TR transposase, which is similar to the IS4-like bacterial transposases, and the ISEU-EX DNA exonuclease (lambda-like exonuclease). Based on the conservation of both proteins in highly divergent transposons, is is clear that they are necessary for transpositions. IS4EU-1_AA is a consensus sequence of a young family of autonomous IS4EU transposons that were active in the mosquito genome in a last few million years. The IS4EU-1_AA transposon is characterized by 15-bp imperfect terminal inverted repeats, TA target site duplications, and it encodes two proteins: (i) the 430-aa transposase, IS4EU-1_AA1p, composed of the THAP DNA-binding N-terminal domain and catalytic "DDE" domain, which is conserved in all IS4EU transposases, and (ii) the 519-aa IS4EU-1_AA2p exonuclease. Questions and comments send to Vladimir Kapitonov.
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Derived: [1] (Consensus) |
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Download Sequence - Format: IG, EMBL, FASTA |
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References: |
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